Dr. Mollie Meffert (Department of Biological Chemistry’s Co-Director) is the recipient of the 2023 Hamilton Smith Award for Innovative Research. Dr. Meffert’s research focuses on post-transcriptional regulation of gene expression in the mammalian nervous system. This has included demonstrating a role for NFkB in dendritic spine morphology, showing how miRNAs sculpt the protein synthesis landscape during the neurotrophin response, and defining the role of the miRNA biogenesis regulating protein, Lin28, in neuronal plasticity in the central and peripheral nervous systems. Most recently, the Meffert lab has optimized an Argonaut Crosslinking and Immunoprecipitation (Ago-CLIP) approach to experimentally define in a genome-wide manner which miRNAs are associated with which mRNAs on the Ago complex in cells and tissues.
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