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Michael Caterina Portrait

Michael Caterina
Professor of Neuroscience
Johns Hopkins University School of Medicine


725 N. Wolfe St. 408 Biophysics Building
Baltimore, MD21205
Office Phone: 410-502-5457
Lab Phone: 410-614-1230
Fax: 410-955-5759
Email: caterina@jhmi.edu
Lab Web Site

Click Here for PDF of CV

TRP channel function in thermosensation, pain, and inflammation

My lab studies the biological functions and biophysical characteristics of a group of ion channel proteins of the Transient Receptor Potential Vanilloid (TRPV) family, TRPV1, TRPV2, TRPV3 and TRPV4.  These channels share the intriguing feature that they can be activated by warm or painfully hot temperatures, as well as by many nonthermal stimuli. For example, TRPV1, the founding member of this family, can be activated by painful heat (>42°C), by protons, or by pungent chemicals such as capsaicin. This channel is strongly expressed in nociceptive neurons and is essential for normal behavioral responses to noxious heat. By examining these channels in recombinant and native systems, and taking advantage of knockout mice lacking one or more subtypes, we are dissecting the biological contributions of these channels to thermosensory and nonthermosensory processes in both neuronal and nonneuronal cells. We are also seeking to more broadly understand the biological and pathophysiological basis of chronic pain.

Current areas of emphasis include:

  1. Understanding the mechanisms by which TRPV1 dynamically alters its selectivity among Ca2+, Na+ and other cations during persistent stimulation, and the biological significance of this plasticity
  2. Understanding the mechanisms by which keratinocytes in the skin contribute to "indirect" thermosensation and pain perception by signaling to epidermal nerve endings
  3. Examination of nonthermosensory roles for TRPV channels in epithelial cells of the skin and urinary bladder, as well as other cell types.
  4. Developing novel assays and reagents for the quantification and characterization of nociception and nociceptive neurons at baseline and under chronic pain conditions.
  5. Characterizing the contributions of distinct subsets of sensory neurons to pain and hyperalgesia.
Recent Publications

Caterina MJ, Schumacher M, Tominaga M,, Rosen TA, Levine JD and Julius, D.  The capsaicin receptor, a heat-activated ion channel in the pain pathway.  (1997) Nature, 389, 816-824. PubMed Reference

Caterina MJ, Rosen A, Tominaga M, Brake AJ, and Julius D (1999) A capsaicin receptor homologue with a threshold for noxius heat. Nature, 398, 436-441. PubMed Reference

Caterina MJ, Leffler A, Malmberg A, Martin W, Trafton J, Petersen-Zeitz KR, Koltzenberg M, Basbaum A and Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313. (cover article) PubMed Reference

Guler A, Lee H, Iida T, Shimizu I,  Tominaga M, and Caterina MJ.  Heat-evoked activation of the ion channel, TRPV4. (2002) J. Neurosci. 22, 6408-6414. PubMed Reference

Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, De Groat WC, Apodaca G, Watkins S, Caterina M.J.  Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. (2002) Nature Neurosci. 5, 856-860. PubMed Reference

Nealen M, Thut P, Gold M and Caterina MJ. TRPM8 is expressed in a subset of cold-responsive trigeminal neurons from rat. (2003) J. Neurophysiology 90, 515-520. PubMed Reference

Chung MK, Lee H and Caterina MJ.  Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes. (2003) J. Biol. Chem. 278, 32037-32046 PubMed Reference

Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ .  TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. (2004) J Biol. Chem. 279, 21569-21575. PubMed Reference

Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ.   2-aminonethoxydiphenyl borate activates and sensitizes the heat-gated ion channel, TRPV3. (2004) J. Neurosci. 24, 5177-5182. PubMed Reference

Iida T, Shimizu I, Nealen ML, Campbell, A., and Caterina MJ.  Attenuated fever response in mice lacking TRPV1. (2005) Neurosci. Lett. 378, 28-33. PubMed Reference

Lee H, Iida T, Mizuno A, Suzuki M, Caterina MJ.   Altered thermal preference in mice lacking TRPV4. (2005) J. Neurosci. 25 1304-10. PubMed Reference

Chung MK, Guler AD, and Caterina MJ.   Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. (2005)  J. Biol Chem. 280, 15928-15941. PubMed Reference

Pogatzki-Zahn E,, Shimizu I, Caterina MJ and Raja SN.   Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain. (2005) Pain, 115, 296-307. PubMed Reference

Shimizu I, Iida T, Guan Y, Zhao C, Raja SN, Jarvis MF, Cockayne DA, and Caterina MJ.    Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. (2005) Pain, 116, 96-108. PubMed Reference

Shimizu I, Iida T, Horiuchi N and Caterina MJ.   5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial TRPV1 agonist in vitro .(2005) J. Pharm. Exp. Ther., 314:1378-85. PubMed Reference

Sidhaye VK, Guler AD, Schweitzer KS, D’Alessio F, Caterina MJ and King LS    Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. (2006) Proc. Natl. Acad. Sci., USA 103(12):4747-52. PubMed Reference

Birder L, Negoita F, Lee H, de Groat W, Kanai A, Barrick S, Meyers S, and Caterina, MJ.    Activation of Urothelial-TRPV4 by 4a-PDD contributes to altered bladder reflexes in the rat. (2007)  J Pharmacol Exp Ther. 323(1):227-35. PubMed Reference

Lumpkin EA and Caterina MJ.   Mechanisms of Sensory Transduction in the Skin. (2007) Nature 445(7130):858-65. PubMed Reference

Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E, Mackie K, Caterina MJ, Walker JM, Fride E and Mechoulam R.    Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain (2008)  FASEB J 22(8):3024-34. PubMed Reference

Chung MK, Guler AD and Caterina MJ. TRPV1 exhibits dynamic ionic selectivity during agonist stimulation. (2008) Nature Neuroscience 11, 555-564 (Highlighted in Nat Neurosci. 2008 May;11(5):528-9) PubMed Reference

Huang SM, Lee H, Chung MK, Park, U, Yu YY, Bradshaw H, Coulombe PA, Walker JM, and Caterina MJ.  Skin keratinocyte TRPV3 ion channels modulate pain sensitivity via prostaglandin E2. (2008) J. Neurosci. 28, 13727-13737. PubMed Reference

Landouré G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH, Choo SS, Phelps CB, Paudel R, Houlden H, Ludlow CL, Caterina MJ, Gaudet R, Kleta R, Fischbeck KH, Sumner CJ. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C Nature Genet. (2010) Feb;42(2):170-4.

Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ, Caterina MJ. TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. (2010)  Nature Immunology  11, 232-239.

Cheng X, Jin, J, Hu L, Shen D, Dong X, Samie MA, Knoff J, Eisinger B, Liu M, Huang SM, Caterina MJ, Dempsey P, Michael E, Dlugosz A, Andrews NC, Clapham DE, and Xu H. A Keratinocyte TRP Channel Controls Hair Morphogenesis and Skin Barrier Formation via EGFR signaling and Transglutaminase Activity. (2010)  Cell  141, 331-343.

Huang SM, Li X, Yu Y, Wang J, Caterina MJ.  TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. (2011) Mol Pain. 2011 May 17;7(1):37 PMID: 21586160

Park U, Vastani N, Guan Y, Raja S, Koltzenberg M. and Caterina MJ.  TRPV2 knockout mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception  (2011) J Neurosci. 31(32):11425-36. PMID: 21832173

Nedungadi TP, Dutta M, Bathina CS, Caterina MJ, Cunningham JT.
Expression and distribution of TRPV2 in rat brain.  (2012) Exp Neurol.  237(1):223-37. PMID: 22750329​​

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