Department of Biological Chemistry - Johns Hopkins University

Faculty

Molecular mechanisms of thermosensation and nociception.

Structural and signaling roles of cytoskeletal assemblies; Epithelial biology in health and disease

Molecular and cellular biology of actin-associated cell junctions.

Biochemistry and molecular biology of protozoan parasites.

Exosome biogenesis, retrovoirus budding, alloimmunity, and animal evolution

Dynamic o-glycosylation of nuclear and cytosolic proteins.

Signals/genes that trigger stem cell/adipose lineage commitment and differentiation; Hypothalamic control of adiposity

Transcriptional regulation of neuronal function in health and disease

Mechanisms of enzyme action; enzymes of DNA and ATP hydrolysis; isomerases; nuclear magnetic resonance and electron spin resonance.

TRP channels and Sensory Signaling

Cellular, molecular, and genetic control of cell motility in development and disease

Global analysis of signal transduction pathways using mass spectrometry; Bioinformatics, sequence databases and annotation

Cell energetics, its molecular and chemical basis and relationship to both disease and to the discovery of new therapies.

Functional specificity and design of signal transduction pathways

Biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades

Protein Folding; NMR characterization of unfolded proteins; protein structure prediction.

Eukaryotic nuclear events: 1- massive sequence changes by RNA editing, and 2- a novel localization process for critical DNA sequences

The role of nucleocytoplasmic glycosylation, O-GlcNAc, in signal transduction.