Myostatin is a secreted protein that normally acts to limit muscle growth. This image shows the expression of myostatin mRNA in developing somites during embryongenesis. Se-Jin Lee lab.

• List BCMB faculty by departmental affiliation.
• List BCMB faculty alphabetically by last name.
• Search BCMB faculty by research interest.
• Biological Chemistry
• Biophysics & Biophysical Chemistry
• Cell Biology
• Molecular Biology & Genetics
• Neuroscience
• Pharmacology
• Physiology

BCMB Faculty in the Department of Biological Chemistry

• Caterina, Michael
  Molecular mechanisms of thermosensation and nociception
• Coulombe, Pierre A.
  Structural and signaling roles of keratin cytoskeletal assemblies; Epithelial differentiation and homeostasis in health and disease
• Craig, Susan
  Cytoskeletal proteins in Cell Adhesion and Motility
• Devreotes, Peter
  Genetic analysis of chemotaxis in eukaryotic cells
• Englund, Paul
  Biochemistry and molecular biology of parasitic protozoa
• Gould, Stephen
  Exosome biogenesis, retrovirus budding, alloimmunity, and animal evolution.
• Hart, Gerald
  Roles of cytoplasmic and nuclear glycosylation in transcription, oncogene function, neurodegenerative disease, and in diabetes
• Meffert, Mollie K.
  The Regulation of Neuronal Gene Expression in Health and Disease
• Montell, Craig
  TRP channels: From Sensory Signaling to Animal Behavior and Neurodegeneration
• Montell, Denise
  Cellular and Molecular Dynamics of Cell Migration
• Pandey, Akhilesh
  Signal transduction; Mass spectrometry; Bioinformatics; Cancer biomarkers
• Pedersen, Peter
  Cell energetics, its molecular and chemical basis and relationship to both disease and to the discovery of new therapies.
• Pomerantz, Joel L.
  Functional Specificity and Design of Signal Transduction Pathways
• Raben, Daniel
  Biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades
• Reddy, Karen
  Understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation
• Sollner-Webb, Barbara
  (1) Nuclear DNA organization and (2) RNA Editing
• Watkins, Paul
  Fatty Acid Activation Enzymes
• Wolfgang, Michael
  CNS control of metabolism; Neurochemistry: novel metabolic enzymes of the CNS.
• Zachara, Natasha
  O-GlcNAc, A Novel Regulator of the Cellular Stress Response and Cell Surival.

BCMB Faculty in the Department of Biophysics & Biophysical Chemistry

• Amzel, L. Mario
  Structural enzymology of redox and phosphoryl-transfer enzymes: MICAL, VP14, PI3K, and Nudix hydrolases. Selected areas of structural thermodynamics.
• Cotter, Robert
  Development of time-of-flight and ion trap mass spectrometry; applications of MALDI and electrospray mass spectrometry to immunology, protein structure analysis and genomics
• Leahy, Daniel
  Three-dimensional structure of proteins and protein complexes involved in cell-cell and cell-matrix interaction and signaling
• Lorsch, Jon
  Mechanisms of eukaryotic translation initiation
• Wade, Herschel
  Molecular basis of multi-ligand•receptor specificity, ligand-dependent transcriptional regulation and bacterial multidrug resistance.
• Wolberger, Cynthia
  Structural and mechanistic basis of transcriptional regulation
• Xiao, Jie
  Quantitative understanding of gene expression and cell division at the single molecule and single cell levels. Single molecule fluorescence microscopy, live cell imaging, fluorescent reporter development.

BCMB Faculty in the Department of Cell Biology

• Andrew, Deborah
  Organogenesis in a model system: Formation of the Drosophila salivary gland and trachea
• Devreotes, Peter
  Genetic analysis of chemotaxis in eukaryotic cells
• Espenshade, Peter
  Mechanisms of Molecular Sensing
• Ewald, Andrew
  Cellular mechanisms and molecular regulation of epithelial morphogenesis during development and breast cancer
• Hubbard, Ann
  Trafficking of Copper-ATPases and Molecular Determinants of Polarity in Epithelial Cells.
• Iijima, Miho
  Lipid Signaling in Chemotaxis
• Inoue, Takanari
  Our lab will use inducible perturbation and simultaneous real-time fluorescent imaging to reveal how elementary signaling modules can be integrated to generate complex chemotactic behaviors. We will also develop and implement an innovative method for probing fast, local signaling events in polarized cells.
• Jensen, Robert
  Mitochondrial dynamics, protein targeting, yeast molecular genetics.
• Kupfer, Abraham (Avi)
  Signaling, cell-cell interaction, intercellular communication, immune cell activation, multi-dimensional imaging, novel biosensors.
• Machamer, Carolyn
  Intracellular protein trafficking; Golgi complex structure/function; apoptosis; intracellular virus assembly; coronaviruses
• Matunis, Erika
  Signals Regulating Stem Cell Self-renewal
• Michaelis, Susan
  Yeast and mammalian cell biology; progeria and lamin A processing; ER quality control and cystic fibrosis, ABC transporters
• Robinson, Douglas
  Cytokinesis and Cell Shape Control
• Sesaki, Hiromi
  Molecular Mechanisms and Physiological Roles of Mitochondrial Fusion and Division
• Wilson, Katherine
  Nuclear envelope proteins and human disease
• Yang, Joy
  Regulation of cell migration by cell-ECM adhesion and integrin signaling.

BCMB Faculty in the Department of Molecular Biology & Genetics

• Boeke, Jef
  Transposition mechanisms; yeast genetics; transcriptional silencing
• Chen, Elizabeth
  Molecular and cellular mechanisms of myoblast fusion
• Clements, Janice
  Molecular Pathogenesis of SIV & HIV
• Corden, Jeffry
  RNA Polymerase II Phosphorylation and Transcription Regulation
• Cormack, Brendan
  Fungal pathogenesis: the host-pathogen interaction for the yeast pathogen Candida glabrata
• Craig, Nancy L.
  Genome plasticity, protein-DNA machines
• Desiderio, Stephen
  Mechanisms of Development in the Immune System
• Feinberg, Andrew
  Epigenetics in development and disease; genomic imprinting
• Green, Rachel
  Molecular switches in the ribosome and their role in regulation
• Greider, Carol
  Telomeres and telomerase in stem cell failure and cancer
• Kolodkin, Alex
  Molecular Mechanisms of Neuronal Growth Cone Guidance
• Lee, Se-Jin
  Growth and differentiation factors, mammalian development
• Nathans, Jeremy
  Molecular mechanisms of retinal development and disease; the role of Frizzled receptors in mammalian development.
• Pan, Duojia D.J.
  Molecular genetics of tumor suppression genes and oncogenes
• Pitha-Rowe, Paula
  
• Reed, Randall
  Molecular mechanisms of signal transduction and neurogenesis in the olfactory system
• Seydoux, Geraldine
  Embryonic Polarity and the Soma-Germline Dichotomy
• Siliciano, Robert
  Host-virus interaction in HIV infection
• Soloski, Mark
  Structure and function of the genes and gene products of the mammalian major histocompatibility complex
• Spencer, Forrest
  
• Urban, Sinisa
  Biochemistry, cell and chemical biology of intra-membrane proteases in cell signalling during development and host-cell invasion by pathogens
• Zack, Donald
  Molecular approaches to the study of retinal development and function

BCMB Faculty in the Department of Neuroscience

• Baraban, Jay
  Molecular mechanisms of neuronal plasticity
• Bergles, Dwight
  Synaptic signaling and neuron-glia interactions in the CNS
• Blackshaw, Seth
  Molecular basis of cell specification in vertebrate retina and hypothalmus
• Caterina, Michael
  Molecular mechanisms of thermosensation and nociception
• Dong, Xinzhong
  Molecular and Genetic Studies of Pain-sensing Neurons
• Ginty, David
  Developmental Neuroscience
• Huganir, Richard
  Regulation of Neurotransmitter Receptor Function and Synaptic Plasticity in the Brain
• Kolodkin, Alex
  Molecular Mechanisms of Neuronal Growth Cone Guidance
• Li, Min
  Molecular regulation of potassium channels in health and in disease
• Marsh-Armstrong, Nick
  Gene regulation, development and disease of the vertebrate retina
• Meffert, Mollie K.
  The Regulation of Neuronal Gene Expression in Health and Disease
• Montell, Craig
  TRP channels: From Sensory Signaling to Animal Behavior and Neurodegeneration
• Nathans, Jeremy
  Molecular mechanisms of retinal development and disease; the role of Frizzled receptors in mammalian development.
• Pevsner, Jonathan
  Molecular basis of neurological disorders
• Reed, Randall
  Molecular mechanisms of signal transduction and neurogenesis in the olfactory system
• Ronnett, Gabriele
  Developmental Neuroscience
• Schnaar, Ronald
  Molecular basis of cell-cell interactions in the nervous system; glycobiology
• Snyder, Solomon H.
  Neural Signaling
• Sockanathan, Shanthini
  Cell fate specification in the central nervous system
• Worley, Paul
  Molecular mechanism of neuronal plasticity
• Yau, King-Wai
  Cellular and Molecular Neuroscience

BCMB Faculty in the Department of Pharmacology

• Ambinder, Richard F.
  Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment
• Cole, Philip
  Chemical approaches to the study of signal transduction, gene expression, and circadian rhythm.
• Cotter, Robert
  Development of time-of-flight and ion trap mass spectrometry; applications of MALDI and electrospray mass spectrometry to immunology, protein structure analysis and genomics
• Gibson, D. Wade
  Herpes virus proteins: synthesis, structure, and function during replication.
• Hardwick, J. Marie
  Molecular mechanisms of programmed cell death and its role in viral pathogenesis
• Hayward, Gary
  Herpesvirus regulation of cellular factors
• Hayward, S. Diane
  Herpesvirus Interactions with Cell Signaling Pathways
• Huganir, Richard
  Regulation of Neurotransmitter Receptor Function and Synaptic Plasticity in the Brain
• Liu, Jun
  Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction, angiogenesis and cell proliferation
• Meyers, Caren L. Freel
  Organic and medicinal chemistry, chemical biology: drug delivery mechanisms in bacteria; development of antibiotic prodrug strategies; study of bacterial isoprenoid biosynthesis; combinatorial biosynthesis; development of potential therapeutic agents
• Robinson, Douglas
  Cytokinesis and Cell Shape Control
• Schnaar, Ronald
  Molecular basis of cell-cell interactions in the nervous system; glycobiology
• Shapiro, Theresa
  Molecular pharmacology of antiparasitic drugs
• Stäger, Simona
  Immunoparasitology; CD8+ T-cells; Leishmania; vaccination
• Stivers, James
  Structural and Chemical Biology of Uracil Metabolism and Applications to Cancer Therapy, Viral Pathogenesis and Acquired Immunity
• Taverna, Sean
  Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.
• Zhang, Jin
  Spatiotemporal Regulation of Protein Kinases and Second Messengers.
• Zhu, Heng
  Signal Transduction, protein network, host-pathogen interaction, protein chip approach to study proteomics

BCMB Faculty in the Department of Physiology

• Claypool, Steven
  The interplay of lipids and proteins in mitochondrial physiology and pathophysiology.
• Guggino, William
  Structure/function studies of Cl- and water channels.
• Hoh, Jan
  Cellular and molecular biophysics; atomic force microscopy; engineered cellular microenvironments; protein micropatterning
• Lutsenko, Svetlana
  Copper homeostasis: mechanism of transport, protein and metabolic networks, integrative approches to human disease
• Maloney, Peter
  Mechanisms of membrane transport; reconstitution and crystallization of membrane function; cystic fibrosis
• Raben, Daniel
  Biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades
• Rao, Rajini
  Discovery and molecular mechanisms of novel ion transporters.
• Reeves, Roger
  Mechanisms of gene action in aneuploidy; complex genetic traits.
• Wong, Guang William
  “Novel Fat tissue-derived endocrine mediators; insulin resistance, diabetes, and obesity”