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Department of Biological Chemistry Logo
Department of
Biological Chemistry
Johns Hopkins University Medicine logo

Selected Research Area: Signal Transduction

Signal Transduction is broadly defined as the mechanisms through which intra- and intercellular signals are generated and metabolized to regulate critical biochemical processes involved in growth, differentiation, and survival.  Our Department explores the mechanistic underpinnings of these pathways at the cellular, genetic, biochemical, and biophysical level.  Such studies provide insights into unappreciated physiological functions of these pathways, and identify new targets for various human diseases.

Michael Caterina photo
TRP channel function in thermosensation, pain, and inflammation

Robert N. Cole photo
Mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer

Seth Margolis photo
Molecular Mechanisms of Synapse Formation in Development and Disease

Mollie K. Meffert photo
The Regulation of Neuronal Gene Expression in Health and Disease

Joel L. Pomerantz photo
Functional Specificity and Design of Signal Transduction Pathways

Daniel Raben photo
Structure, function, regulation and interfacial enzymology of lipid metabolizing enzymes involved in signal transduction cascades; biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades.

Michael Wolfgang photo
Cellular and organismal metabolism

Natasha Zachara photo
O-GlcNAc, A Novel Regulator of the Cellular Stress Response and Cell Surival.

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