TRP channel function in thermosensation, pain, and inflammation
Mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer
Mechanism and biology of small silencing RNAs
Bacterial cell biology: cytoskeletal function during growth and division
Exosome biogenesis and retrovirus budding
Roles of cytoplasmic and nuclear glycosylation in transcription, oncogene function, neurodegenerative disease, and in diabetes
Molecular Mechanisms of Synapse Formation in Development and Disease
The Regulation of Neuronal Gene Expression in Health and Disease
Molecular dissection of host-pathogen interactions and the evolution of virulence strategies in natural reservoirs
Signal transduction; Mass spectrometry; Bioinformatics; Cancer biomarkers
Cell energetics, its molecular and chemical basis and relationship to both disease and to the discovery of new therapies.
Functional Specificity and Design of Signal Transduction Pathways
Structure, function, regulation and interfacial enzymology of lipid metabolizing enzymes involved in signal transduction cascades; biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades.
Understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation
Human amyloid A protein structure and pathophysiology
Protein folding; NMR characterization of partially folded proteins; protein structure prediction
Cellular and organismal metabolism
O-GlcNAc, A Novel Regulator of the Cellular Stress Response and Cell Surival.